A nurse is reinforcing teaching with a newly licensed nurse about age-related changes that affect medication administration for older adult clients. Which of the following information should the nurse include?

A. Renal function typically declines with age, leading to a decrease in glomerular filtration rate (GFR) and renal blood flow. As a result, medications may be excreted more slowly from the body, leading to an increased risk of drug accumulation and potential toxicity. Adjustments in medication dosages or dosing intervals may be necessary to account for this age-related change. B. Brain receptors do not change significantly. However, older adults may require lower doses to achieve the same therapeutic effect due to reduced receptor sensitivity. C. Gastric emptying tends to slow down with age rather than increase. Delayed gastric emptying can affect the absorption of orally administered medications, leading to unpredictable drug levels and potentially reduced efficacy. D. Hepatic function generally decreases with age, leading to a decline in the metabolic capacity of the liver. This can result in slower drug metabolism and clearance, prolonging the duration of action of medications and increasing the risk of adverse effects.