A nurse is reviewing a new prescription for propranolol 200 mg PO daily divided in equal doses every 12 hr for a client who has migraine headaches during the premenstrual period. Available is propranolol solution 4 mg/mL. How many mL should the client self-administer per dose? (Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

Determine the single dose (Desired Dose) in milligrams (mg). Ordered dose: 200 mg daily divided in equal doses every 12 hr. Dosing frequency: q12h (2 doses per day) Single Dose (mg) = 200 mg/day / 2 doses/day = 100 mg/dose. Available: 4 mg/mL. Calculate the volume to administer in milliliters (mL). Volume (mL) = Desired Dose (mg) / Available Concentration (mg/mL) = 100 mg / 4 mg/mL = 25 mL.