A nurse is reviewing the home medications of a client who recently had transient ischemic attacks and is to begin taking clopidogrel. The nurse should instruct the client that which of the following over-the-counter medications interacts adversely with clopidogrel?

A. Vitamin D: Vitamin D is a supplement used to support bone health and calcium regulation. It does not have a known adverse interaction with clopidogrel and does not increase the risk of bleeding when taken concurrently. B. Ranitidine: Ranitidine is an H2 receptor antagonist used to reduce stomach acid. It has minimal interaction with clopidogrel and does not significantly impact bleeding risk, making it generally safe to use alongside antiplatelet therapy. C. Naproxen: Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of gastrointestinal bleeding when used with clopidogrel, an antiplatelet agent. Combining these medications heightens the risk of serious bleeding complications and should be avoided without provider guidance. D. Docusate sodium: Docusate sodium is a stool softener that facilitates easier bowel movements. It does not have a significant interaction with clopidogrel and does not affect bleeding risk, making it generally safe for clients requiring antiplatelet therapy.