A nurse is reviewing the list of medications for a client who has a new prescription for fluoxetine. The nurse should identify that which of the following medications is contraindicated with fluoxetine?
Explanation & Rationale
A. Prednisolone: Corticosteroids like prednisolone are not contraindicated with fluoxetine. Although concurrent use may slightly increase the risk of gastrointestinal irritation or affect blood glucose levels, there is no major drug interaction that prevents their coadministration. B. Lispro: Lispro is a rapid-acting insulin used for diabetes management. Fluoxetine does not directly contraindicate insulin use, though it may slightly affect glycemic control in some clients. Close monitoring of blood glucose is recommended, but the combination is generally safe. C. Calcitonin: Calcitonin, used for conditions like osteoporosis, does not have significant interactions with fluoxetine. There is no contraindication for concurrent use, and standard monitoring is sufficient. D. Phenelzine: Phenelzine is a monoamine oxidase inhibitor (MAOI). Combining MAOIs with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), can precipitate serotonin syndrome, a potentially life-threatening condition characterized by confusion, hyperthermia, autonomic instability, and neuromuscular abnormalities. Concurrent use is strictly contraindicated.