A nurse is reviewing the medical record of a client who has a new prescription for selegiline transdermal. Which of the following findings should the nurse identify as a contraindication for administration of this medication to the client?
Explanation & Rationale
A. Has a history of gastric reflux: Gastric reflux is not a contraindication for selegiline transdermal. This medication is primarily concerned with interactions that may affect the central nervous system or blood pressure, rather than gastric issues. B. Has a history of cholelithiasis: A history of gallstones (cholelithiasis) is not a contraindication for selegiline transdermal. This medication does not have a known direct effect on the gallbladder or bile ducts. C. Drinks a glass of orange juice daily: There is no significant interaction between selegiline and orange juice. Clients should, however, avoid tyramine-rich foods to prevent hypertensive crises, but orange juice is not a concern in this case. D. Takes St. John's Wort daily: This is a contraindication. Selegiline is a monoamine oxidase inhibitor (MAOI), and taking it in combination with St. John's Wort can increase the risk of serotonin syndrome, a potentially life-threatening condition. This interaction should be avoided.