A nurse is reviewing the medical record of a client who has a new prescription for clozapine for the treatment of schizophrenia. Which of the following findings indicates a contraindication to clozapine?

Choice A reason: Asthma is not a contraindication to clozapine use. While respiratory conditions require monitoring, they do not prevent clozapine therapy. Choice B reason: A fasting blood glucose of 120 mg/dL indicates impaired fasting glucose but is not a contraindication. Clozapine can cause metabolic side effects, but this value alone does not prohibit use. Choice C reason: Clozapine carries a risk of agranulocytosis, a severe reduction in white blood cells. A WBC count of 3.3/mm³ is dangerously low and contraindicates clozapine therapy due to risk of life-threatening infection. Choice D reason: Migraines are not a contraindication to clozapine. They are unrelated to the drug’s hematologic risks.