A nurse is reviewing the medical record of a client who has schizophrenia and is taking clozapine. Which of the following findings should the nurse identify as a contraindication to the administration of clozapine?
Explanation & Rationale
A. Fasting blood glucose 100 mg/dL: This level is within the normal range and does not contraindicate the use of clozapine. Monitoring blood glucose is important due to the risk of metabolic syndrome, but a normal level is not a concern. B. Hgb 14 g/dL: Hemoglobin levels in this range are normal and indicate adequate oxygen-carrying capacity. This finding does not contraindicate the use of clozapine. C. Heart rate 58/min: A heart rate of 58 beats per minute is considered bradycardic but does not directly contraindicate the use of clozapine. Monitoring cardiovascular health is important, but this alone is not a reason to withhold the medication. D. WBC count 2,900/mm³: This finding is significant because clozapine can cause agranulocytosis, a potentially life-threatening decrease in white blood cells. A WBC count below 3,000/mm³ is a contraindication for clozapine administration, as it increases the risk of infection and other complications. Therefore, this finding indicates that clozapine should not be administered.