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    Ati rn comprehensive predictor 2023 proctored exam

    A nurse is reviewing the medical record of a male client who has schizophrenia and is taking clozapine. Which of the following findings should the nurse identify as a contraindication to the administration of clozapine?

    Explanation & Rationale

    A. Fasting blood glucose 124 mg/dL (70 to 110 mg/dL): Mildly elevated fasting glucose indicates impaired fasting glucose or prediabetes but is not an absolute contraindication for clozapine. Monitoring glucose is important due to the risk of metabolic syndrome, but it does not preclude administration. B. Heart rate 58/min: Mild bradycardia is not a contraindication for clozapine. Clozapine can cause tachycardia, hypotension, or orthostatic changes, so monitoring is necessary, but a heart rate of 58/min alone does not prohibit use. C. Absolute neutrophil count 1,300/mm³ (2,500 to 8,000/mm³): Clozapine carries a risk of severe neutropenia and agranulocytosis. An ANC below 1,500/mm³ is a contraindication to starting or continuing clozapine because it significantly increases the risk of life-threatening infection. D. Hgb 12.5 g/dL (14 to 18 g/dL): Mild anemia is not a contraindication for clozapine. Hemoglobin should be monitored, but this level does not directly increase the risk of clozapine-related adverse effects.

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