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    RN Comprehensive Predictor 2026 Proctored Exam V2

    A nurse is reviewing the medical record of a male client who has schizophrenia and is taking clozapine. Which of the following findings should the nurse identify as a contraindication to the administration of clozapine?

    Explanation & Rationale

    Clozapine carries a black box warning for agranulocytosis — a severe reduction in neutrophils. An absolute neutrophil count (ANC) below 1,500/mm³ is a contraindication to clozapine therapy. An ANC of 1,300/mm³ is critically low and requires immediate withholding of the drug and notification of the provider. Regular WBC and ANC monitoring is mandatory for all clients on clozapine. The other findings — bradycardia, elevated glucose, and slightly low hemoglobin — are concerning but are not contraindications specific to clozapine.

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