A nurse is reviewing the medication record of a client who has a new prescription for fluoxetine. Which of the following medications should the nurse expect the provider to discontinue 2 weeks before starting fluoxetine treatment?

The nurse should expect the provider to discontinue phenelzine 2 weeks before starting fluoxetine treatment. Phenelzine is a monoamine oxidase inhibitor (MAOI) and should not be taken with fluoxetine, which is a selective serotonin reuptake inhibitor (SSRI). Taking these two medications together can cause a dangerous drug interaction known as serotonin syndrome. a) Levothyroxine is a thyroid hormone replacement medication and does not interact with fluoxetine. b) Acetaminophen is a pain reliever and does not interact with fluoxetine. c) Simvastatin is a cholesterol- lowering medication and does not interact with fluoxetine.