A nurse is reviewing the phases of pharmacokinetics. Which of the following phases is the change of a drug into a less or more potent or more soluble form after it passes through the liver?

A. Excretion is the removal of the drug from the body, typically through the kidneys, and is not related to changes in the drug's potency or solubility. B. Absorption is the process of the drug entering the bloodstream, not a process that alters the drug's chemical form. C. Distribution is the process by which the drug is spread throughout the body’s tissues and organs, not the phase where the drug is altered. D. Metabolism, primarily occurring in the liver, involves the conversion of drugs into more water-soluble forms, which can either increase or decrease their potency.