A nurse is teaching a class on prenatal development. The nurse should instruct that advanced maternal age increases the risk for which of the following. conditions?

Rationale: A. Down syndrome incidence increases with advanced maternal age (typically ≥35 years) due to a higher risk of chromosomal nondisjunction during meiosis. B. Asthma is influenced more by genetic and environmental factors rather than maternal age. C. Spina bifida is primarily associated with folic acid deficiency rather than maternal age. D. Facial malformations can occur due to various teratogens or genetic factors but are not specifically linked to advanced maternal age.