A nurse is teaching a client about ibuprofen. Which of the following cues should the nurse recognize as a potential complication of ibuprofen?

A. Black, tarry stools (melena) are a classic sign of gastrointestinal bleeding, which is a well-known complication of NSAIDs such as ibuprofen. NSAIDs inhibit prostaglandin synthesis, reducing the protective lining of the stomach and increasing the risk of ulcers and GI bleeding. This is an important adverse effect that requires immediate attention, especially in clients who have other risk factors such as a history of peptic ulcers, concurrent anticoagulant use, or advanced age. B. Yellowing of the skin (jaundice) indicates liver dysfunction. While liver injury is rare with ibuprofen, it is not a common or typical complication. Hepatotoxicity is more often associated with medications such as acetaminophen (in overdose) or other hepatotoxic drugs. C. NSAIDs like ibuprofen are more likely to cause fluid retention and increased blood pressure rather than decreased blood pressure. Hypotension is not a usual complication unless severe bleeding or other acute reactions occur. D. NSAIDs are not associated with changes in appetite. This is not a recognized adverse effect and is unrelated to ibuprofen therapy.