A nurse is teaching a client who has a new prescription for captopril. Which of the following instructions should the nurse include in the teaching?

A. Grapefruit juice is not a concern with captopril. It is more commonly associated with calcium channel blockers, which are affected by grapefruit juice. B. Captopril can be taken with or without food. It is not necessary to take it with food, although taking it on an empty stomach can improve absorption. C. A persistent cough is a well-known side effect of ACE inhibitors like captopril. The client should monitor for this symptom and report it to their healthcare provider. D. Captopril does not have a direct effect on heart rate. It is an ACE inhibitor that primarily lowers blood pressure, so holding the medication for a heart rate below 60/min is not necessary.