A nurse is teaching a client who has a new prescription for colchicine to treat gout. Which of the following instructions should the nurse include?

A. "Monitor for muscle pain.": Colchicine can cause serious adverse effects such as rhabdomyolysis and myopathy, particularly in clients with renal impairment or when combined with statins. Teaching the client to report new muscle pain ensures early detection and intervention to prevent complications. B. "Expect to have increased bruising.": Colchicine does not commonly cause increased bleeding or bruising. Bruising is more associated with anticoagulants or antiplatelet medications. C. "Increase your intake of grapefruit juice.": Grapefruit juice can increase serum colchicine levels by inhibiting its metabolism, which raises the risk of toxicity. Clients should avoid grapefruit juice rather than increase intake while on colchicine. D. "Take this medication with food if nausea develops.": Colchicine should be taken without food because meals can decrease its absorption. Although nausea is a common side effect, taking it with food is not recommended as a management strategy.