A nurse is teaching a client who has a new prescription for simvastatin. Which of the following instructions should the nurse include?

A. Brown-colored urine is not a typical side effect of simvastatin. Dark urine may indicate liver damage, which should be reported. B. The best time to take simvastatin is usually in the evening, as cholesterol production is higher at night. C. Ringing in the ears is not a known side effect of simvastatin. It may be caused by other conditions, but it is not linked to statins. D. Grapefruit juice can interact with simvastatin and increase the risk of muscle pain or damage, so it should be avoided.