A nurse is teaching a client who has a new prescription for transdermal nitroglycerin to treat angina pectoris. Which of the following instructions should the nurse include in the teaching?

A. "Apply the transdermal patch in the same location as the previous patch.": It is important to rotate the application sites to prevent skin irritation and ensure proper absorption. Applying the patch in the same location repeatedly can cause skin irritation. B. "Apply a new transdermal patch once a week.": Transdermal nitroglycerin patches are typically applied every 24 hours, not once a week. The patches are designed to deliver a consistent amount of medication throughout the day, and they need to be replaced regularly. C. "Apply a new transdermal patch when chest pain is experienced.": Transdermal nitroglycerin is used for continuous prevention of angina, not for acute chest pain. A patch should be applied regularly as prescribed, not on an as-needed basis for chest pain. D. "Apply the transdermal patch in the morning.": The patch should be applied in the morning and worn for 12 to 14 hours, followed by a patch-free period to prevent tolerance. This helps to maintain effectiveness while minimizing the risk of developing tolerance to the medication.