A nurse is teaching a client who has rheumatoid arthritis about taking methotrexate. Which of the following information should the nurse include?

A. While methotrexate can cause nausea, antiemetics are typically taken before administration if needed, not 1 hour after. B. Taking NSAIDs with methotrexate can increase the risk of toxicity by reducing renal clearance of the drug, so it should be done cautiously and only under medical supervision. C. Methotrexate can cause renal toxicity, so drinking 2 to 3 liters of water per day helps prevent kidney damage and supports safe drug elimination. D. An alcohol-based mouthwash can irritate mucous membranes, especially if the client develops stomatitis, a common side effect. A non-alcohol-based rinse is recommended instead.