A nurse is teaching a client who is taking metformin XR for type I diabetes mellitus. Which of the following instructions should the nurse include in the teaching?

A. Increased perspiration is more commonly associated with hypoglycemia or medications like sulfonylureas, not metformin. B. Metformin XR (extended-release) tablets should not be crushed or chewed, as this can alter the release mechanism and increase the risk of side effects. C. Metformin XR should be taken with a meal to reduce gastrointestinal side effects such as nausea and diarrhea. D. Orange-colored urine is not a known side effect of metformin; this is more commonly associated with medications like rifampin.