A nurse is teaching a client who is to receive long-term antibiotic therapy through a peripherally inserted central catheter (PICC) line. Which of the following statements should the nurse include in the teaching?

A. The wrist is not an appropriate site for PICC insertion. A PICC line is typically inserted into a large vein in the upper arm, such as the basilic or cephalic vein. B. While it's important to avoid excessive or repetitive bending at the elbow, the client does not need to keep the arm completely straight at all times. Normal movement is allowed with precautions. C. A PICC line can stay in place for weeks to months, depending on the client's needs and condition. Routine replacement after 3 weeks is not standard practice unless there’s a complication. D. A 10-mL syringe is recommended for flushing a PICC line, as using smaller syringes creates higher pressure, which can damage the catheter.