A nurse is teaching a client who takes acetaminophen daily to manage mild knee pain. The nurse should instruct the client to monitor for which of the following adverse reactions to this medication?

A. Muscle pain – Muscle pain is not a common adverse effect of acetaminophen. It may be associated with statins or other medications, but not this analgesic. B. Tinnitus – Tinnitus is more commonly associated with salicylates like aspirin, not acetaminophen. C. Jaundice – Acetaminophen is metabolized by the liver, and hepatotoxicity is a serious adverse effect, especially with high doses or long-term use. Jaundice (yellowing of the skin or eyes) is a key sign of liver damage and should be reported immediately. D. Hyperglycemia – Acetaminophen does not significantly affect blood glucose levels and is not associated with hyperglycemia.