A nurse is teaching a group of nurses about the importance of prophylactic antimicrobial therapy. Which information should the primary nurse include in the teaching? (Select All That Apply).

A. Incorrect: Prophylactic antibiotics are not given for a diagnosed respiratory infection. Instead, targeted treatment based on the pathogen is used. B. Correct: Clients with prosthetic heart valves need prophylactic antibiotics before dental procedures to prevent infective endocarditis. C. Incorrect: Upper respiratory infections are often viral, and antibiotics are not routinely needed. D. Correct: Clients undergoing orthopedic surgery may require prophylactic antibiotics to prevent surgical site infections.