A nurse manager in a health clinic is discussing complications associated with sexually transmitted infections (STIs) with a newly licensed nurse. Which of the following statements should be included in the discussion?

A. "A complication of syphilis during pregnancy is low-birth-weight infants.": Syphilis during pregnancy is more strongly associated with serious outcomes such as stillbirth, neonatal death, congenital syphilis, and prematurity. While low birth weight can occur, it is not the most defining or commonly emphasized complication compared with these severe outcomes. B. "Human papillomavirus can lead to cancer of the cervix.": Persistent infection with high-risk strains of HPV, particularly types 16 and 18, is a well-established cause of cervical cancer. HPV integrates into cervical epithelial cells, causing dysplasia that can progress to malignancy if not detected and treated early. C. "A complication of chlamydia in males is meningitis.": Chlamydia primarily affects the genitourinary tract and can lead to complications such as epididymitis, prostatitis, and infertility in males. Meningitis is not a complication of chlamydial infection. D. "Herpes simplex virus can lead to pelvic inflammatory disease.": Pelvic inflammatory disease is most commonly caused by ascending bacterial infections such as chlamydia and gonorrhea. Herpes simplex virus causes localized ulcerative lesions and does not typically result in PID.