A patient diagnosed with Acute Kidney Injury (AKI) secondary to SIRS, at risk of progressing to Multi-Organ Dysfunction Syndrome (MODS) is admitted for treatment. The susceptibility to nephrotoxic effects necessitates vigilant nursing care.

A. Increase the frequency of vital signs monitoring to detect SIRS-related changes: This is important for systemic assessment but does not directly protect the kidneys from further injury. B. Carefully monitor and document the patient's serum drug levels to avoid toxicity: The kidneys excrete many medications. In AKI, impaired clearance increases the risk of drug accumulation and toxicity, making drug level monitoring critical. C. Administer nephrotoxic medications early in the day to facilitate drug clearance: Timing does not reduce nephrotoxicity. The type and dosage of drug, along with renal function, are more important considerations. D. Prioritize nutritional support: While essential for healing, nutrition does not directly prevent nephrotoxicity. Renal-safe feeding is needed, but drug monitoring is the priority for kidney protection.