A patient is prescribed 150 mg of Sertraline once daily. The available tablet is 50 mg. How many tablets should the nurse administer?

Choice A reason: Five tablets (250 mg) exceed the prescribed 150 mg, risking Sertraline overdose. This SSRI increases serotonin, and excessive dosing may cause serotonin syndrome, with symptoms like agitation or seizures. Scientifically, precise dosing prevents adverse neurological effects, ensuring safe treatment for depression or anxiety. Choice B reason: Four tablets (200 mg) overdose the patient, exceeding the 150 mg prescription. Sertraline’s serotonin-enhancing effects can lead to toxicity, causing symptoms like nausea or tremors. Scientifically, overdosing disrupts neurotransmitter balance, risking serious side effects, while correct dosing ensures effective mood stabilization without harm. Choice C reason: Three tablets (150 mg) match the prescribed dose, ensuring therapeutic serotonin levels. Scientifically, accurate Sertraline dosing optimizes neurotransmitter balance, effectively treating depression or anxiety by enhancing serotonin activity in the prefrontal cortex and amygdala, reducing symptoms without risking toxicity or side effects. Choice D reason: Two tablets (100 mg) underdose the patient, providing insufficient serotonin modulation. Scientifically, subtherapeutic Sertraline levels fail to address neural imbalances in depression or anxiety, risking persistent low mood or panic symptoms, as inadequate dosing doesn’t sufficiently enhance neurotransmitter activity for effective treatment.