A patient is taking an antacid concurrently with ketoconazole. The antacid inhibits the dissolution of ketoconazole. Which term accurately describes this result?.

Choice A rationale: An allergic reaction refers to an immune response to a foreign substance. It does not describe the interaction between an antacid and ketoconazole. Choice B rationale: Displacement refers to one drug replacing another at the drug-binding site on proteins, altering the distribution of the displaced drug. It does not describe the interaction between an antacid and ketoconazole. Choice C rationale: Accumulation refers to the buildup of a drug in the body due to inadequate metabolism or excretion. It does not describe the interaction between an antacid and ketoconazole. Choice D rationale: A drug interaction occurs when the effect of one drug is altered by the administration of another drug. Antacids can slow the dissolution and absorption of ketoconazole, which is a type of drug interaction.