A patient with a gastric ulcer is ordered sucralfate (Carafate). How does this medication works?
Explanation & Rationale
A. Calm the patient to reduce acid production. This description is not accurate for sucralfate. Calming the patient to reduce acid production is typically associated with medications like proton pump inhibitors (PPIs) or H2 receptor blockers. B. Block the H2 receptors. Blocking H2 receptors is the mechanism of action for H2 receptor blockers, such as ranitidine. It is not the mechanism of action for sucralfate. C. Neutralize the gastric acids. Neutralizing gastric acids is the mechanism of action for antacids, such as aluminum hydroxide or calcium carbonate. Sucralfate works differently; it forms a protective coating on the gastric lining rather than directly neutralizing acids. D. Coat the gastric lining. This is the correct mechanism of action for sucralfate. It forms a protective coating on the gastric lining, adhering to the ulcer site and providing a barrier against gastric acid.