A patient with asthma is prescribed a mast cell stabilizer for long term management. The nurse is teaching the patient about this medication. Which statement by the patient indicates a correct understanding of the expected pharmacological action of mast cell stabilizers?
Explanation & Rationale
A. Mast cell stabilizers work by preventing the release of histamine and other inflammatory mediators from mast cells, which reduces airway inflammation and bronchoconstriction: This statement accurately describes the mechanism of action of mast cell stabilizers. By preventing degranulation, these medications help control chronic inflammation and reduce asthma symptoms over time. B. Mast cell stabilizers function by directly blocking the effects of histamine already released from mast cells to alleviate symptoms: Mast cell stabilizers do not block histamine receptors or counteract histamine already released. Antihistamines perform that role, not mast cell stabilizers. C. Mast cell stabilizers work by enhancing the degranulation process of mast cells, leading to increased histamine release and airway constriction: Enhancing degranulation would worsen asthma symptoms. Mast cell stabilizers aim to prevent, not promote, the release of inflammatory mediators. D. Mast cell stabilizers work by promoting the degranulation of mast cells, facilitating the release of inflammatory mediators to improve airway function: Promoting degranulation is the opposite of the intended effect. Increasing mediator release would exacerbate inflammation and bronchoconstriction rather than improving airway function.