A young adult client is prescribed misoprostol to prevent gastric ulcers caused by frequent use of nonsteroidal anti-inflammatory agents for an autoimmune disorder. For which reason will the nurse question giving the client a dose of this medication?

A. The client was taking NSAIDs: Misoprostol is specifically indicated for the prevention of NSAID-induced gastric ulcers. Its prostaglandin-like action protects the gastric mucosa from damage caused by these medications, making this an appropriate use. B. The client could possibly be pregnant: Misoprostol is contraindicated in pregnancy because it can induce uterine contractions, leading to miscarriage, premature labor, or birth defects. Pregnancy must be ruled out before administration. C. Can cause constipation: Misoprostol is more commonly associated with side effects such as diarrhea and abdominal cramping, not constipation. Gastrointestinal upset is a known but usually manageable adverse effect. D. Needs to be taken without food: Misoprostol is typically taken with food to reduce gastrointestinal side effects. Taking it without food is not recommended and does not impact its ulcer-protective action significantly.