According to the Monroe-Kellie doctrine, which of the following statements is true regarding the three essential components of the skull (brain tissue, blood, and CSF)?

A. According to the Monroe-Kellie doctrine, the skull is a closed compartment, and the total volume of brain tissue, blood, and cerebrospinal fluid (CSF) must remain constant. If one component increases, the others must decrease to maintain normal intracranial pressure (ICP). B. Even small changes in volume can affect ICP and brain function if compensation mechanisms are exceeded. C. The skull is rigid and does not expand, so any volume increase without compensation leads to increased ICP. D. The components are interrelated and changes in one directly affect the others due to the closed nature of the intracranial space.