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Hepatotoxicity: Acetaminophen overdose or chronic high-dose use can lead to liver injury and potentially acute liver failure. Hepatotoxicity is a major concern, particularly in clients with preexisting liver disease or chronic alcohol use. Stevens-Johnson syndrome: Although rare, acetaminophen can trigger severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis. These life-threatening reactions require immediate discontinuation of the drug and medical intervention.