After chemotherapy has begun for a child with acute leukemia, which of the following interventions to prevent acute tumor lysis syndrome would the nurse perform?

Rationale: A. Oxygenation: While maintaining adequate oxygen is important for overall care, it does not directly prevent acute tumor lysis syndrome (TLS), which is caused by the rapid breakdown of malignant cells and release of intracellular contents. B. Pain management: Managing discomfort is necessary for patient well-being, but it does not address the metabolic imbalances (hyperkalemia, hyperuricemia, hyperphosphatemia, hypocalcemia) that occur in TLS. C. Hydration: Adequate IV hydration increases urine output, helps flush out excess potassium and uric acid, and reduces the risk of uric acid crystal precipitation in the kidneys. D. Corticosteroids: While steroids may be part of leukemia treatment protocols, they are not the primary intervention to prevent TLS and may even contribute to rapid tumor breakdown if used in high doses.