All four patients below have classic migraine headaches. Which of the following patients can you safely prescribe Triptan therapy?

A. A 40-year-old who uses Ambien (Zolpidem) for insomnia: Triptans can be safely prescribed in patients taking Zolpidem because there is no significant pharmacologic interaction between SSRIs/5-HT1 agonists and sedative-hypnotics. Concomitant use does not increase cardiovascular risk or contraindicate therapy. B. A 26-year-old who might be pregnant: Triptans are generally not recommended during pregnancy due to limited safety data and potential fetal risk. Alternative treatments or non-pharmacologic approaches are preferred until pregnancy is confirmed. C. A 42-year-old who takes blood pressure medicine: Many triptans cause vasoconstriction, which can increase blood pressure. Use in patients with uncontrolled hypertension or certain antihypertensive regimens requires caution, making them higher risk for adverse cardiovascular events. D. A 55-year-old who uses sublingual nitroglycerin: Concomitant use of triptans and nitrates is contraindicated because both cause vasoconstriction and vasodilation interactions, increasing the risk of severe hypotension or cardiac ischemia. Triptans should be avoided in this patient.