Apparent dependence and/or tolerance in a patient with chronic pain should not impede titration of medical therapy to an effective dose.

Patients with chronic pain may develop tolerance and physical dependence due to long-term opioid therapy, which are expected physiologic adaptations. These factors should not prevent titration to achieve adequate analgesia, as undertreatment can lead to unnecessary suffering. Careful monitoring and individualized dosing ensure safety while maintaining effective pain control.