Bedwetting alarms are considered __________ for enuresis, while medications such as desmopressin are typically __________.

Rationale for correct choices: First-line treatments: Bedwetting alarms are considered first-line therapy because they use behavioral conditioning to help the child recognize bladder fullness during sleep. This non-pharmacologic approach addresses the underlying issue and has long-term efficacy. Second-line treatments: Desmopressin is typically reserved for cases where behavioral interventions alone are insufficient or rapid symptom control is needed. It reduces urine production at night but does not correct underlying behavioral patterns. Rationale for incorrect choices: Ineffective treatments: Both bedwetting alarms and desmopressin have demonstrated efficacy when used appropriately, so labeling either as ineffective is inaccurate.