Below are a list of characteristics specific to Lymphoma. Please idicate if the characteristic is specific to Hodgkins Lymphoma or Non- Hodgkins Lymphoma by selecting the appropriate column.

Rationale: • May be associated with HIV and autoimmune diseases: Non-Hodgkin’s lymphoma (NHL) is more commonly linked with immunodeficiency states such as HIV and autoimmune disorders, increasing the risk of NHL development. • Associated with Epstein Barr Virus (EBV): EBV infection is strongly linked to Hodgkin’s lymphoma, particularly certain subtypes like mixed cellularity and lymphocyte-depleted Hodgkin’s lymphoma. • Characterized by the presence of Reed-Sternberg Cells: Reed-Sternberg cells, large abnormal multinucleated B cells, are the pathological hallmark specific to Hodgkin’s lymphoma and are absent in NHL. • The three main signs and symptoms associated with this type of lymphoma are low-grade fever, night sweats, and weight loss: These constitutional “B symptoms” are classic for Hodgkin’s lymphoma and often guide diagnosis and prognosis. • Involves multiple nodes and extranodal involvement is common: Non-Hodgkin’s lymphoma tends to be more widespread at diagnosis, frequently involving multiple lymph node groups and extranodal sites such as the gastrointestinal tract or bone marrow. • Localized to a single group of nodes: Hodgkin’s lymphoma characteristically starts in a single lymph node region and spreads in a contiguous manner to adjacent nodes before involving distant sites.