Complete the sentences by selecting the correct option from each drop-down menu. While providing education, the nurse explains that indomethacin reduces pain and inflammation bydropdown . Before initiating therapy, the nurse should assess the client for dropdown. The nurse also teaches the client to monitor for and report any dropdownpromptly.

Rationale for correct choices: Inhibition of prostaglandin synthesis: Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, swelling, and inflammation by inhibiting prostaglandin synthesis, which mediates the inflammatory response in gout. History of gastrointestinal bleeding or ulcers: NSAIDs can cause gastric irritation, ulcers, and bleeding. Assessing for a history of GI problems is essential before initiating therapy to prevent complications. Signs of GI bleeding: Clients taking NSAIDs should monitor for signs such as black stools, vomiting blood, or severe abdominal pain and report them promptly, as these are serious adverse effects. Rationale for incorrect choices: Stimulating serotonin production / increasing prostaglandin release: These do not describe the mechanism of action of indomethacin. In fact, NSAIDs reduce prostaglandin production rather than increase it. History of depression / frequent headaches: These are not primary risk factors related to NSAID therapy for gout. Mild fatigue / increased urination: While side effects can occur, these are not the primary serious adverse effects the client needs to be taught to monitor.