Differentiate between tolerance and addiction in the context of pain management.

A. Tolerance leads to compulsive drug-seeking behavior: Compulsive drug-seeking behavior is the hallmark of addiction, which is a psychological and behavioral disorder. Tolerance is a purely physiological adaptation where the body requires higher doses of a drug to achieve the same effect. Tolerance does not inherently mean a person will develop addictive behaviors. B. Physical dependence and addiction are the same: Physical dependence involves the occurrence of withdrawal symptoms when a drug is stopped, whereas addiction is characterized by the psychological drive to use a substance despite harm. A patient can be physically dependent on a medication without being addicted to it. These are distinct clinical phenomena. C. Addiction involves compulsive use regardless of harm: Addiction is defined by impaired control over drug use, craving, and continued use despite negative physical, social, or legal consequences. It involves a complex interplay of genetics, brain chemistry, and environment. It is a chronic disease of brain reward and motivation. D. Tolerance is characterized by withdrawal symptoms upon cessation: Withdrawal is the clinical manifestation of physical dependence, not tolerance. Tolerance specifically refers to the diminishing effect of a drug over time with repeated use. While they often occur together in long-term opioid use, they represent different physiological processes.