Drugs with a dropdown therapeutic index require close monitoring due to the risk for dropdown

Narrow therapeutic index: Drugs with a narrow therapeutic index have a small range between therapeutic and toxic doses. Small variations in dose or blood levels can result in subtherapeutic effects or toxicity, requiring careful monitoring of serum drug levels, kidney and liver function, and patient response. • Risk for toxicity: Because the margin between effective and harmful doses is small, clients taking drugs with a narrow therapeutic index are at higher risk for adverse effects and toxicity. Close monitoring helps detect early signs of toxicity and prevents serious complications.