Exhibits For each statement, click to indicate whether the statements by the student nurse indicate understanding or no understanding of naloxone. Each row must have one option selected.

"When given IV, naloxone starts working immediately and can last several hours.": Although naloxone acts rapidly when given intravenously, its duration of action is relatively short—usually 30 to 90 minutes. Because naloxone’s effects may wear off before the opioid is fully cleared, repeated dosing and close monitoring are essential to prevent recurrence of respiratory depression. "If the first dose does not work, you can give as many doses as needed to reverse respiratory depression.": Naloxone dosing can be repeated safely as needed to reverse opioid-induced respiratory depression, especially with long-acting opioids. Proper titration minimizes risk of precipitated withdrawal while ensuring airway safety. "Naloxone will not affect the client's level of pain.": This statement shows lack of understanding since naloxone reverses opioid effects including analgesia. Administering naloxone can precipitate acute pain and withdrawal symptoms in opioid-dependent clients by blocking opioid receptors. "You can give naloxone intravenously, intramuscularly, or subcutaneously.": Naloxone is versatile and can be administered through various routes IV, IM, SC, and intranasally depending on clinical circumstances and urgency. "Naloxone works best on pure agonist opioids.": Naloxone effectively reverses respiratory and CNS depression caused by pure opioid agonists like morphine and fentanyl. Its effectiveness is reduced with mixed agonist-antagonists or partial agonists due to receptor affinity differences.