Fill in the blank ____ _____ is approved for use in cataplexy and excessive sleepiness. This controlled substance is tightly regulated through a central pharmacy in the U.S. and has been labeled a "date rape" drug by the press due to the potential when used with alcohol.

A. Carbon isolate: Carbon isolate is not a pharmacologic agent and has no role in the treatment of sleep disorders. It does not affect cataplexy or excessive daytime sleepiness. B. Glycerol oxidase: Glycerol oxidase is an enzyme used in biochemical assays and is not a therapeutic agent for sleep disorders or narcolepsy. C. Sodium oxybate: Sodium oxybate is approved for treating cataplexy and excessive daytime sleepiness in narcolepsy. It is a controlled substance due to its sedative properties and potential for misuse, earning media attention as a “date rape” drug when combined with alcohol. Its distribution is strictly regulated through a central pharmacy program. D. Orexin oxidase: Orexin (hypocretin) is involved in wakefulness regulation, but “orexin oxidase” is not an approved medication. Drugs targeting orexin receptors exist, but they are used for insomnia rather than cataplexy or excessive sleepiness.