For each clinical finding, click to specify whether the finding is associated or is not associated with lithium toxicity.

• Drowsiness: Drowsiness or sedation is a common early sign of lithium toxicity, reflecting its effects on the central nervous system. CNS depression may progress to confusion or ataxia if toxicity worsens. Monitoring alertness helps identify toxicity early and prevent severe complications such as seizures or coma. • Tremors: Fine or coarse hand tremors are frequently observed with lithium toxicity. Tremors occur due to the drug’s effect on neuromuscular function and electrolyte balance. Recognizing tremors early allows dose adjustment and prevents further neurologic impairment. • Depression: While mood changes are a primary indication for lithium therapy, depression itself is not a manifestation of lithium toxicity. Toxicity affects neurologic and renal systems rather than directly inducing depressive symptoms. Persistent depressive symptoms may indicate underlying psychiatric illness rather than adverse drug effects. • Photosensitivity: Photosensitivity is not associated with lithium therapy or toxicity. While other medications may cause skin reactions to sunlight, lithium toxicity presents with neurologic, gastrointestinal, and renal manifestations, not cutaneous photosensitivity.