For the child with transposition of the great vessels, which drug may be given to allow the Patent Ductus Arteriosus (PDA) to remain open until surgery?

A. Digoxin is used to strengthen cardiac contractions and treat heart failure, but it does not maintain ductal patency. B. Ibuprofen is a prostaglandin inhibitor, and would actually cause closure of the PDA, which is contraindicated in transposition of the great vessels. C. Prostaglandin E (such as alprostadil) is administered to keep the ductus arteriosus open, allowing mixing of oxygenated and deoxygenated blood to improve oxygenation until surgical correction is performed. D. Indomethacin is also a prostaglandin inhibitor used to close a PDA, not keep it open.