Four clients are receiving tyrosine kinase inhibitors (TKIs). Which of these four clients would the nurse assess first?

Rationale: A. This is a common, expected dermatologic side effect of tyrosine kinase inhibitors (TKIs), often referred to as hand-foot skin reaction. While it can cause discomfort and impact quality of life, it is not an immediate threat to the client’s health and can be managed with topical treatments, emollients, and dose adjustments if severe. B. This value indicates severe hypokalemia, which is potentially life-threatening. Low potassium levels can cause cardiac dysrhythmias, muscle weakness, and cardiac arrest. Clients taking TKIs are at increased risk of cardiac complications, making this finding the highest priority for assessment and intervention. C. A small, short-term weight gain is not clinically significant and may result from minor variations in fluid or dietary intake. The nurse should monitor for rapid weight gain exceeding 2–3 lb (1–1.5 kg) in 24 hours, which could indicate fluid retention or heart failure, but this current finding does not warrant immediate action. D. This value is within the normal range (8.5–10.5 mg/dL) and does not represent a risk requiring urgent intervention. It indicates stable calcium balance and no acute metabolic disturbance.