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    Pharmacology Chicago State University Proctored Exam

    How many 300 mg Aspirin suppositories can be prepared from 31 g cocoa butter base. Density factor of Aspirin is 1.3 Weight of blank suppository base is 2 g

    Explanation & Rationale

    Step 1 is to convert the aspirin dose per suppository to grams 300 ÷ 1000 = 0.3 Result at this step = 0.3 g Step 2 is to calculate the weight of the base displaced by the drug (Drug weight ÷ Density factor) (0.3 ÷ 1.3) = 0.2307 Result at this step = 0.2307 g Step 3 is to calculate the actual weight of the base needed per suppository (Weight of blank base - Weight of base displaced) 2 - 0.2307 = 1.7693 Result at this step = 1.7693 g Step 4 is to calculate the total number of suppositories (Total base available ÷ Base needed per suppository) 31 ÷ 1.7693 = 17.52 Result at this step = 17.52 Step 5 is to round down to the nearest whole number for completed suppositories 17.52 ≈ 17 Answer: 17

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