In a patient receiving hydrocodone for moderate pain, which of the following should the nurse prioritize to assess for potential adverse effects? (Select all that apply.)

Choice A reason: Hydrocodone is metabolized in the liver. Monitoring liver function is important, especially in patients with pre-existing hepatic impairment or those taking other hepatotoxic drugs. Choice B reason: Kidney function affects drug clearance. Impaired renal function can lead to accumulation of hydrocodone and increased risk of toxicity. Choice C reason: Sedation is a common adverse effect of opioids. Excessive sedation can progress to respiratory depression, making it a critical parameter to monitor. Choice D reason: Orthostatic hypotension may occur due to opioid-induced vasodilation and decreased sympathetic tone. Monitoring helps prevent falls and related injuries.