In SIRS and MODS, which of the following factors eventually compromise organ perfusion?

A. Hypermetabolism: While it increases the body’s energy demands, hypermetabolism itself does not directly compromise perfusion. It contributes to catabolism and worsening organ function over time, but perfusion deficits are due to vascular and circulatory issues. B. Hypotension and micro-emboli formation: Hypotension reduces overall blood flow to organs, and micro-emboli can block capillaries, both of which impair oxygen and nutrient delivery, leading to organ dysfunction/failure. C. Hyperperfusion: This is the opposite problem - increased blood flow. SIRS and MODS are marked by hypoperfusion. D. Hyperglycemia: Elevated glucose contributes to inflammation and poor outcomes, but it does not directly cause impaired perfusion like hypotension and emboli do.