Intake of a substance in a large enough quantity to interfere with normal functioning is:

A. overdose: Refers to consuming a toxic amount that may be life-threatening, often requiring emergency intervention. B. intoxication: Intoxication is the physiological and psychological disruption caused by a substance, impairing functioning. C. tolerance: Tolerance refers to needing more of a substance to achieve the same effect, not acute interference with function. D. dependency: Dependency is a chronic condition characterized by compulsion and inability to stop use, not a single event of impairment.