Isosorbide mononitrate modified release formula is structured to provide a nitrate free period. The nurse understands that the rationale for this period is to:

A. Decrease allergic reactions: Nitrate-free periods are not primarily designed to address allergic reactions. B. Decrease tolerance to effects: Nitrates, including isosorbide mononitrate, can lead to the development of tolerance when used continuously. The nitrate-free period helps to minimize this tolerance, allowing the medication to remain effective over time. C. Prevent reflex tachycardia: While nitrate use can sometimes cause reflex tachycardia, the nitrate-free interval is not specifically aimed at preventing this. D. Increase absorption: The nitrate-free period does not influence the absorption of the medication itself.