lloperidone has a potent a1 antagonism. What side-effect is associated with a1 antagonism?

A. Retinal detachment: Retinal detachment is unrelated to alpha-1 adrenergic receptor blockade. It is typically associated with trauma, high myopia, or age-related changes in the vitreous, not with antipsychotic pharmacology. B. Gum recession: Gum or periodontal issues are not linked to alpha-1 antagonism. They are more commonly associated with poor oral hygiene, certain medications like phenytoin, or systemic conditions, rather than antipsychotic side effects. C. Orthostatic Hypotension: Alpha-1 adrenergic receptors help maintain vascular tone. Potent alpha-1 antagonism, as seen with iloperidone, causes vasodilation and impaired compensatory vascular response, leading to orthostatic hypotension, dizziness, and risk of falls. D. Hyperprolactinemia: Hyperprolactinemia occurs primarily due to D2 receptor blockade in the pituitary, not alpha-1 adrenergic antagonism. While iloperidone may elevate prolactin minimally, this is independent of its alpha-1 effects.